• Risa Ahdyani Universitas Muhammadiyah Banjarmasin
  • Sri Rahayu universitas muhammadiyah banjarmasin
  • Irfan Zamzani
  • Andika Andika Universitas Muhammadiyah Banjarmasin


Herbal cosmeceuticals are cosmetic-pharmaceutical hybrids intended to enhance health and beauty through natural ingredients that are applied onto skin surface. The ability of an ingredient in enhancing skin's biological texture and function depends on the delivery system to reach specific targeted sites in an amount sufficient to exert an effect in a controlled manner. The novel approach that could be used in the delivery of herbal cosmeceuticals is nanoparticle-based delivery system. Many researches have been conducted on the development of nanoparticle-based delivery system containing natural ingredients such as gotu kala extract, rosemary extract, orange peel extract, ginseng extract, basil extract, safflower extract, resveratrol, and Taduvelai extract. Based on the literature study of previous researches reported that nanoparticle-based delivery system has been successfully delivered those natural ingredients through certain mechanism in enhancing activity as skin antiaging, skin whitening, antiacne, and hair care product.



Alan S. Verkman. 2011. Aquaporints at a Glance. Journal of Cell Science. 124, 2107-2112. doi:10.1242/jcs.079467
Alexa Patzelt, Fanny Knorr, Ulrike Blume-Peytavi, Wolfram Sterry, dan Ju¨rgen Lademann. 2008. Hair follicles, their disorders and their opportunities. Drug Discovery Today: Disease Mechanisms. Vol. 5 No. 2. dOI: 10.1016/j.ddmec.2008.04.006
Alexander Vaiserman, Alexander Koliada, Alina Zayachkivska dan Oleh Lushchak. 2020. Nanodelivery of Natural Antioxidants: An Anti-aging Perspective. Frontiers in Bioengineering and Biotechnology. Vol. 7. 447. doi: 10.3389/fbioe.2019.00447
Alka Lohani, Anurag Verma, Himanshi Joshi, Niti Yadav, dan Neha Karki. 2014. Review Article: Nanotechnology-Based Cosmeceuticals. Hindawi. Journal of Pharmaceutics.
Annika Vogt, Behazine Combadiere, Sabrina Hadam, Karola M. Stieler, Juergen Lademann, Hans Schaefer, Brigitte Autran, Wolfram Sterry dan Ulrike Blume-Peytavi. 2006. 40 nm, but not 750 or 1,500 nm, Nanoparticles Enter Epidermal CD1aþ Cells after Transcutaneous Application on Human Skin. Journal of Investigative Dermatology. Vol. 126. 1316–1322. doi:10.1038/sj.jid.5700226
Das, D. K., Mukherjee, S., & Ray, D. (2010). Resveratrol and red wine, healthy heart and longevity. Heart Failure Reviews, 15(5), 467–477. s10741-010-9163-9
Draelos, Z.D. 2011. The Art and Science of New Advances in Cosmoceuticals. Clin Plastic Surg. 38:397-407.
Eliana B. Souto, Ana Rita Fernandes, Carlos Martins-Gomes, Tiago E. Coutinho , Alessandra Durazzo, Massimo Lucarini, Selma B. Souto, Amélia M. Silva dan Antonello Santini. 2020. Review: Nanomaterials for Skin Delivery of Cosmeceuticals and Pharmaceuticals. Applied Sciences. 10, 1594; doi: 10.3390/app10051594
Fauzi, Aceng R, Nurmalina, dan Rina. 2012. Merawat Kulit dan Wajah. Jakarta: Gramedia.
Gaurav Pant, Nitesh Nayak, R, dan Gyana Prasuna. 2012. Enhancement of antidandruff activity of shampoo by biosynthesized silver nanoparticles from Solanum trilobatum plant leaf. Appl Nanosci 3:431–439. doi: 10.1007/s13204-012-0164-y
Schaefer, H. J dan Lademann. 2001. The Role of Follicular Penetration A Differential View. Skin Pharmacol Appl Skin Physiol;14(suppl 1):23–27. doi: 1422–2868/01/0147–0023$17.50/0
Hu, Y., Xeng, Hl, Juang, J., Jian, L., Chen, J., dan Zeng., Q. 2020. Review: Traditional Asian Herbs in Skin Whitening: The Current Development and Limitations. Frontiers in Pharmacology, 11: 1-10.
Hye-Ji Lee, Ha-Kyoung Kwon, Hye Su Kim, Moon Il Kim dan Hye-Jin Park 1. 2019. Hair Growth Promoting Eect of 4HGF Encapsulated with PGA Nanoparticles (PGA-4HGF) by –Catenin Activation and Its Related Cell Cycle Molecules. International Journal of Molecular Sciences. Int. J. Mol. Sci, 20, 3447; doi:10.3390/ijms20143447
Inoue Y, Hasegawa S, Yamada T, Date Y, Mizutani H, Nakata S, Matsunaga K, Akamatsu H. 2013. Analysis of the effects of hydroquinone and arbutin on the differentiation of melanocytes. Biol Pharm Bull 36:1722–1730
J. Lademann, F. Knorr, H. Richter, S. Jung, M. C. Meinke, E. Rüh U. Alexie, M. Calderon dan A. Patzelt. 2015. Hair follicles as a target structure for nanoparticles. Journal of Innovative Optical Health Sciences. Vol. 8, No. 4. doi: 10.1142/S1793545815300049
Jamie Rosen, Angelo Landriscina dan Adam J. Friedman. 2015. Review: Nanotechnology-Based Cosmetics for Hair Care. Ccosmetic. Vol. 2, 211-224; doi:10.3390/cosmetics2030211
Jin Chen, Ning Wei, Maria Lopez-Garcia, Dianna Ambrose, Jason Lee dan Colin Annelin, Teresa Peterson. 2017. Development and evaluation of resveratrol, Vitamin E, and epigallocatechin gallate loaded lipid nanoparticles for skin care applications. European Journal of Pharmaceutics and Biopharmaceutics. 117; 286-291.
Jin Ju Park, Su Jung Hwang, Yu Sun Kang, Jisung Jung, Suryeon Park, Jee Eun Hong, Yohan Park dan Hyo-Jong Lee. 2019. Synthesis of arbutin–gold nanoparticle complexes and their enhanced performance for whitening. Archiver of Pharmacal Research.
Joshi, L.S. dan Pawar, H.A. 2015. Herbal Cosmetics and Cosmeceuticals: An Overview. Nat Prod Chem Res. 3(2): 1-8.
Kumar Ganesan, Kumeshini Sukalingam dan Baojun Xu. 2017. Solanum trilobatum L. Ameliorate Thioacetamide-Induced Oxidative Stress and Hepatic Damage in Albino Rats. Antioxidan,6,68: doi: 10.3390
Kumar N, Tharatha S, Chaiyasut C. Development and validation of simple isocratic high performance liquid chromatography- ultraviolet (HPLC-UV) method for determination of safflower yellow in Carthamus tinctorius L.-loaded nanostructured lipid carriers (NLC). Afr J Pharm Pharmacol 2011;5(20):2335-41.
Kumar, N., dan Chaiyasut, C. 2015. Hair Growth Promoting Activity Of Carthamus tinctorius Florets Extract- Loaded Nanostructured Lipid Carriers. International Journal of Pharmacy and Pharmaceutical; 7(2):252-257.
Linda Yulianti, Kusmarinah Bramono, Etik Mardliyati dan Hans-Joachim Freisleben. 2016. Effects of Centella asiatica Ethanolic Extract Encapsulated in Chitosan Nanoparticles on Proliferation Activity of Skin Fibroblasts and Keratinocytes, Type I and III Collagen Synthesis and Aquaporin 3 Expression In Vitro. J Pharm Biomed Sci. Vol. 06. No. 05; 315-327, doi:
Lucia Montenegro, Lorella Pasquinucci, Agata Zappala, Santina Chiechio, Rita Turnaturi dan Carmela Parenti. 2017. Rosemary Essential Oil-Loaded Lipid Nanoparticles: In Vivo Topical Activity from Gel Vehicles. Pharmaceutics, Vol 9, 48; doi:10.3390/pharmaceutics9040048
Maira N Pereira, Camila Y Ushirobira, Marcilio SS Cunha-Filho, Guilherme M Gelfuso dan Tais Gratieri. 2018. Nanotechnology advances for hair loss. Therapeutic Delivery. Vol. 9 No. 8; 593-603. doi: 10.4155/tde-2018-0025
Naphatsorn Kumar dan Chaiyavat Chaiyasut. 2014. Hair Growth Promoting Activity Of Carthamus Tinctorius Florets Extract-Loaded Nanostructured Lipid Carriers. International Journal of Pharmacy and Pharmaceutical Sciences. Vol. 7, Issue 2, 252-257
Oktaviani, M., dan Yenny, S. W. 2019. Perkembangan Penggunan Kosmestikal Herbal pada Terapi Melasma. Jurnal Kesehatan Andalas, 8(3): 717-725.
Raj, S., Jose, S., Sumod, U.S., dan Sabitha, M. 2012. Nanotechnology in Cosmetics: Opportunities and Challenges. J Pharm Bioallied Sci. 4(3): 186-193.
Sahu, J., Rathi, B., Koul, S., dan Khosa R.L. 2013. Soalnum tribolatum (Soalanceae)-an Overview. Journal of Natural Remedies. 13(2):76-80.
Satishkumar, P., Preethi, J., Vijayan R., Yusoff, A. R. M., Ameen, F., Suresh, S., Balagurunathan, R., dan Palvannan, T. 2016. Antiacne, anti-dandruff and anti-breast cancer efficacy of green synthesised silver nanoparticles using Coriandrum sativum leaf extract. Journal of Photocemistry & Photobiology, B:Biology163, 69-76.
Shreya Kaul, Neha Gulati, Deepali Verma, Siddhartha Mukherjee, dan Upendra Nagaich. 2018. Review Article: Role of Nanotechnology in Cosmeceuticals: A Review of Recent Advances. Hindawi. Journal of Pharmaceutics.
Silpa Raj, Shoma Jose, Sumod U. S dan Sabitha M. 2012. Nanotechnology in cosmetics: Opportunities and challenges-Riview Article. Journal of Pharmacy and Bioallied Sciences. Vol. 4 Issue. 3. doi: 10.4103/0975-7406.99016
Sinha, P., Srivastava, S., Mishra, N., dan Yadav, N.P. 2014. Review Article: New Perspective on Antiacne Plant Drugs: Contribution to Modern Therapeutics. Biomed Research International, 1-14.
Sovan Lal Pal, Utpal Jana, P. K. Manna, G. P. Mohanta dan R. Manavalan. 2011. Nanoparticle: An overview of preparation and characterization. Journal of Applied Pharmaceutical Science 01 (06): 228-234
Tada M, Kohno M, Niwano Y. 2014. Alleviation effect of arbutin on oxidative stress generated through tyrosinase reaction with L- tyrosine and L-DOPA. BMC Biochem 15:23
Titta H.S., Ahmad N., Resi A., (2013). Formulasi Sediaan Masker Gel Dari Ekstrak Metanol Daun Teh Hijau (Camellia sinensis L.) Dan Madu Hitam (Apidorsata) Sebagai Antioksidan. Kartika Jurnal Ilmiah Farmasi : 1(17-23).
Tong Ho Kang, Hye Min Park, Yoon-Bum Kim, Hyunae Kim, Nami Kim, Jae-Ho Do, Chulhun Kang, Yunhi Cho dan Sun Yeou Kim. 2009. Effects of red ginseng extract on UVB irradiation-induced skin aging in hairless mice. Journal of Ethnopharmacology. 123; 446-451. doi: 10.1016/j.jep.2009.03.022.
VJ Mohanraj dan Y Chen. 2006. Nanoparticles-A Review. Tropical Journal of Pharmaceutical Research. 5 (1): 561-573
Zhu, W., dan Gao, J. 2008. Review : The Use of Botanical Extracts as Topical Skin-Lightening Agents for the Improvement of Skin Pigmentation Disorders. Journal of Investigative Dermatology Symposium Proceedings, 13(1): 20-24.
Zuly Elizabeth Jiménez-Pérez, Priyanka Singh, Yeon-Ju Kim, Ramya Mathiyalagan, Dong-Hyun Kim, Myoung Hee Lee dan Deok Chun Yang. 2018. Applications of Panax ginseng leaves-mediated gold nanoparticles in cosmetics relation to antioxidant, moisture retention, and whitening effect on B16BL6 cells. Journal of Ginseng Research. Vol 42: 327-333.
How to Cite
AHDYANI, Risa et al. REVIEW : PENGEMBANGAN SISTEM PENGHANTARAN BERBASIS NANOPARTIKEL DALAM SEDIAAN KOSMESETIKA HERBAL. JCPS (Journal of Current Pharmaceutical Sciences), [S.l.], v. 4, n. 1, p. 289-299, nov. 2020. ISSN 2598-2095. Available at: <>. Date accessed: 18 may 2021.